A further case of rocuronium-induced anaphylaxis treated with sugammadex.

Editor—We thank Drs Banerjee and Saghal for their interest in our meta-analysis addressing the efficacy of perioperative pregabalin in acute postoperative pain. Our literature search produced only 11 valid randomized controlled trials meeting the criteria for analysis. We refrained from performing a subgroup analysis based on different types of surgery because the number of included studies would be too small. It is also possible that patients who had received preoperative pregabalin would show a reduced intraoperative analgesic requirement. However, our meta-analysis was not designed to analyse intraoperative analgesic consumption. Furthermore, some studies in our review used pregabalin after operation. It is true that there are differences in dosing frequencies of pregabalin, but we chose to look at ‘pregabalin’ vs ‘no pregabalin’ in our study. With regard to the variable analgesic strategies in the different studies, we also refrained from subgroup analysis because of the small number of studies. This point was highlighted in our discussion as a limitation of our meta-analysis. We had considered the influence of ondansetron, droperidol, and dexamethasone on postoperative nausea and vomiting in the analysis. These drugs were used both in the control and study groups in the studies. Therefore, the influence of pregabalin can still be compared.